The patient presented by Prof. Everaert is a 55-year-old female administrator whose medical history includes hypertension controlled with amlodipine and vaginal hysterectomy for prolapse. She experiences nocturia two to three times per night and has a history of urgency incontinence and daytime frequency, which resolved with solifenacin. Prof. Everaert reviews clinical data on persisting nocturnal polyuria in patients under therapy for overactive bladder and discusses treatment recommendations. According to randomized, placebo-controlled trials, antidiuretic therapy, such as desmopressin, is effective and well-tolerated; however, gender differences in the antidiuretic response should be taken into account.