Introduction & Objectives: The benign prostatic hyperplasia (BPH) is the result of aging in men and to have MEtabolic syndrome (MtS) is recently one of the causing factors in development of BPH. We investigated impact of neck circumference (NC) for benign prostatic hyperplasia (BPH) patients with metabolic syndrome (MtS). Additionally, we determined dose response to alpha-blockers and cut-off values for NC and waist circumference (WC), in this patients.
Material & Methods: Non-randomized, open-labelled, and multi-centre study was conducted between March 2014 and September 2015. The BPH patients were enrolled and were divided into 2 groups according to have MtS (Group 1;n=94) and not to have MtS (Group 2;n=103). Demographic data, anthropometric measurements, blood analyses, uroflowmetric parameters, post voiding residual urine (PVR), prostate volume, quality of life (QoL) index, NC, WC were recorded. Both groups were administered oral alpha-blockers and response to treatment was evaluated. Receiver-operating characteristic (ROC) curves were obtained and significant p was p<0.05.
Results: In total, 197 patients were enrolled with mean age of 60.5±8.1 years. Mean NC and WC were higher in MtS patients (p<0.001). Uroflowmetry parameters and QoL indexes were comparable between groups before treatment. International prostate symptom score, uroflowmetry parameters, and QoL were significant developed in Group 2 than Group 1, at 1st and 6th months of treatment with alpha-blockers. Success rate in treatment was significant higher in Group 2 than Group 1 (p<0.001).
Cut-off values were 42.5cm and 113.5cm for NC and WC respectively, as taking response to alphablockers in BPH patients with MtS.
Conclusions: MtS can be related with BPH and can negatively affect on response to alpha-blocker treatment. NC can be used for predicting response to alpha-blocker treatment in BPH patients with MtS.
