Upcoming event

Haptoglobin polymorphism – an explanation for global polyuria?


Interview with Prof. Marie-Astrid Denys

Hypothesis / aims of study

Haptoglobin (Hp) is an acute phase, haemoglobin-binding plasma protein that occurs in three different phenotypes: Hp1-1, Hp2-1 and Hp2-2. This polymorphism is associated with functional differences, leading to important clinical consequences. For example, Hp1 1 phenotypes show higher blood pressures and are more likely to be salt sensitive, while Hp2 2 phenotypes are more likely to be salt resistant (1-2). Because (nocturnal) polyuria has also been related to alterations in blood pressure and disorders in sodium clearance, the aim of this study was to explore associations between Hp polymorphism and diuresis rate in adults.